中国普外基础与临床杂志

中国普外基础与临床杂志

甲状旁腺全切除+前臂自体移植术对肾功能衰竭继发甲状旁腺功能亢进合并关节周围软组织钙化患者的疗效分析

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目的 探讨甲状旁腺全切除+前臂自体移植术(TPT+AG)对肾脏功能衰竭(简称肾衰)继发甲状旁腺功能亢进(简称甲旁亢)患者关节周围软组织钙化的疗效。 方法 回顾性分析 广东医科大学附属医院 2015 年 4 月至 2017 年 4 月期间收治的 11 例肾衰继发甲旁亢合并关节周围软组织钙化患者的临床资料,均采用 TPT+AG 治疗,比较手术前后血清甲状旁腺激素(PTH)、钙、磷水平、钙磷乘积变化情况,并观察术后关节周围软组织钙化改善的情况。 结果 11 例患者术后第 6 个月时血磷、钙磷乘积均在正常范围内,有 10 例患者在术后 6 个月于体表均未及原有肿物,临床观察肿物消失最短时间为 2 个月,其原有的活动障碍、局部麻木、疼痛等不适症状完全消失,仅 1 例患者术后肘关节肿物缩小不明显。 结论 本研究有限病例的初步研究结果提示,对于肾衰继发甲旁亢合并关节周围软组织钙化的患者,TPT+AG 是有效的治疗方法,患者可能仅通过 TPT 就可使关节周围软组织钙化明显缩小或者完全消除。

关键词: 甲状旁腺全切除+前臂自体移植术; 肾脏功能衰竭继发甲状旁腺功能亢进; 关节周围软组织钙化; 疗效

引用本文: 张智, 李建文, 陈伟杰, 黎思毅, 许托, 覃文懿, 蔡文松, 徐波. 甲状旁腺全切除+前臂自体移植术对肾功能衰竭继发甲状旁腺功能亢进合并关节周围软组织钙化患者的疗效分析. 中国普外基础与临床杂志, 2018, 25(2): 225-228. doi: 10.7507/1007-9424.201709015 复制

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