中国普外基础与临床杂志

中国普外基础与临床杂志

DNMT1 基因 rs16999593 位点的多态性与乳腺癌易感性关系的 meta 分析

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目的 采用 meta 分析的方法评价 DNA 甲基转移酶 1(DNA methyltransferase 1,DNMT1)基因 rs16999593 位点的多态性与乳腺癌发病的关系。 方法 计算机检索 PubMed、EMbase、Web of Science、中国知网、万方、中国生物医学文献数据库及维普数据库中关于 DNMT1 基因多态性与乳腺癌发病关系的病例对照研究,检索时间均为建库至 2017 年 3 月。由两位评价者按照纳入和排除标准独立筛选文献,并对纳入文献进行方法学质量评价。提取相关资料,采用 RevMan 5.3 软件进行 meta 分析。 结果 最终纳入 5 项病例对照研究,共计 1 741 例乳腺癌患者和 1 917 位健康对照者。meta 分析结果显示:显性遗传模型 [OR=0.63,95% CI 为(0.30,1.30),P=0.21]、纯合子模型 [OR=1.01,95% CI 为(0.70,1.47),P=0.95]、杂合子模型 [OR=0.44,95% CI 为(0.18,1.04),P=0.06] 及等位基因模型 [OR=1.29,95% CI 为(0.90,1.86),P=0.16] 均与乳腺癌的发生无关,但隐性遗传模型 [OR=1.74,95% CI 为(1.01,3.00),P=0.04]与乳腺癌的发生有关。 结论 在亚洲人群中,DNMT1 基因 rs16999593 位点的 TT 基因型是乳腺癌发病的保护因素。

Objective To systematically review the correlation between polymorphism of DNA methyltransferase 1(DNMT1) rs16999593 and the susceptibility of breast cancer. Methods Databases such as PubMed, EMbase, Web of Science, Chinese Biomedical Literature Database, CNKI, WanFang, and VIP database were searched from inception to Mar. 2017 to collect case-control studies on the correlation between DNMT1 rs16999593 C/T polymorphism and the susceptibility of breast cancer. Two reviewers independently identified the literatures according to inclusion and exclusion criterias, extracted data, and assessed the quality of the included studies. The meta-analysis was performed by using RevMan 5.3 software. Results A total of 5 studies involving 1 741 cases and 1 917 control subjects were included. The results of meta-analysis showed that, dominate model [TT+TC vs. CC: OR=0.63, 95% CI was (0.30, 1.30), P=0.21], homozygous model [TT vs. CC: OR=1.01, 95% CI was (0.70, 1.47), P=0.95], heterozygous model [TC vs. CC: OR=0.44, 95% CI was (0.18, 1.04), P=0.06], and additive model [T vs. C: OR=1.29, 95% CI was (0.90, 1.86), P=0.16] were not significantly related to breast cancer, but recessive gene model was related to breast cancer [TT vs. TC+CC: OR=1.74, 95% CI was (1.01, 3.00), P=0.04]. Conclusion The current studies showed that, DNMT1 rs16999593 TT genotype decreases the susceptibility of breast cancer.

关键词: 乳腺癌; DNA 甲基转移酶 1; 基因多态性; meta 分析

Key words: breast cancer; DNA methyltransferase 1; gene polymorphism; meta-analysis

引用本文: 龙斌斌, 张超, 王玲玲, 王耕. DNMT1 基因 rs16999593 位点的多态性与乳腺癌易感性关系的 meta 分析. 中国普外基础与临床杂志, 2018, 25(6): 721-727. doi: 10.7507/1007-9424.201711041 复制

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1. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
2. DeSantis C, Ma J, Bryan L, et al. Breast cancer statistics, 2013. CA Cancer J Clin, 2014, 64(1): 52-62.
3. DeSantis C, Siegel R, Bandi P, et al. Breast cancer statistics, 2011. CA Cancer J Clin, 2011, 61(6): 409-418.
4. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
5. Giacinti L, Claudio PP, Lopez M, et al. Epigenetic information and estrogen receptor alpha expression in breast cancer. Oncologist, 2006, 11(1): 1-8.
6. Chen T, Hevi S, Gay F, et al. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet, 2007, 39(3): 391-396.
7. Ye C, Beeghly-Fadiel A, Lu W, et al. Two-stage case-control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk. Breast Cancer Res Treat, 2010, 121(3): 765-769.
8. Xiang G, Zhenkun F, Shuang C, et al. Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among Chinese Han women in the Heilongjiang Province. Clin Breast Cancer, 2010, 10(5): 373-377.
9. Sun MY, Yang XX, Xu WW, et al. Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China. Genet Mol Res, 2012, 11(4): 4330-4341.
10. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
11. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0. 2011-03. http://www.cochrane-handbook.org/.
12. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
13. Tao R, Chen Z, Wu P, et al. The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females. Tumour Biol, 2015, 36(12): 9849-9855.
14. 孙敏英. 雌激素合成、代谢相关基因和 DNMTs 单核苷酸多态性与中国汉族女性乳腺癌易感性的关联研究. 广州: 南方医科大学, 2012.
15. 陶然. EZH2 和 DNMT1 基因多态性、蛋白表达对中国广东地区汉族女性三阴性乳腺癌易感性的影响. 贵阳: 贵阳医学院, 2014.
16. 郭家权, 陈纯静, 陈恩, 等. 乳腺癌与 MICA 基因多态性的相关性研究. 激光生物学报, 2015, 24(2): 170-174, 169.
17. 周鑫, 曹勇, 罗杰, 等. CD24 基因多态性与乳腺癌遗传易感性的关系. 中南大学学报 (医学版), 2013, 38(11): 1122-1129.
18. Tuerxun·MAIMAITI, Hamulati·WUPUER, XIA Kun, et al. The effect of single and combined genotypes of CYP1A1, CYP1B1, NET and DAT1 on breast cancer susceptibility in a Han Chinese population. Life Sci Res, 2015, 19(6): 521-529.
19. 许晔琼, 何帮顺, 邓齐文, 等. Fas/FasL 基因多态性与乳腺癌发生的相关性. 临床检验杂志, 2013, 31(12): 941-944.
20. 邱秀娟, 成芳, 高俊. 中国人群 FGFR2 基因多态性与乳腺癌易感相关性研究的 Meta 分析. 中华肿瘤防治杂志, 2015, 22(3): 227-234.
21. 李卿, 王红梅, 刘燕玲, 等. IL-10 (-1082A/G) 基因多态性和乳腺癌的相关性: Meta 分析. 现代生物医学进展, 2017, 17(5): 820-825.
22. 魏晓东, 张可, 么坤, 等. MDM2 启动子 SNP309 多态性与亚洲人群乳腺癌易感性关系的 Meta 分析. 世界科技研究与发展, 2015, 37(4): 377-380.
23. 李琳琳, 梁媛, 陈申, 等. XRCC1 Arg399Gln 位点多态性与乳腺癌易感性的 Meta 分析. 中国肿瘤, 2015, 24(3): 223-228.
24. Valinluck V, Sowers LC. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res, 2007, 67(3): 946-950.
25. Kanai Y. Genome-wide DNA methylation profiles in precancerous conditions and cancers. Cancer Sci, 2010, 101(1): 36-45.
26. 武兴. DNMT1 基因多态性与胃癌患者预后的研究. 长春: 吉林大学, 2016.
27. 何帮顺, 潘玉琴, 朱成宾. 甲基化转移酶基因多态性与前列腺癌发病的相关性研究. 中华男科学杂志, 2014, 20(12): 1077-1081.
28. 王玲. DNA 甲基转移酶 1 基因多态性和被动吸烟与宫颈癌的相关性研究. 兰州: 兰州大学, 2014.
29. Montgomery KG, Liu MC, Eccles DM, et al. The DNMT3B C→T promoter polymorphism and risk of breast cancer in a British population: a case-control study. Breast Cancer Res, 2004, 6(4): R390-R394.