中国普外基础与临床杂志

中国普外基础与临床杂志

伴乳头状癌核特征的非浸润性滤泡性甲状腺肿瘤的分子研究进展

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目的 总结伴乳头状癌核特征的非浸润性滤泡性甲状腺肿瘤(noninvasive follicular thyroid neoplasm with papillary-like nuclear features,NIFTP)的分子研究进展。 方法 通过检索国内外与 NIFTP 分子研究相关的文献资料,并进行综述。 结果 NIFTP 中最常见的分子突变是鼠肉瘤病毒致癌基因同源物(rat sarcoma viral oncogene homolog,RAS),并可见 Raf 激酶蛋白的 β 异构体K601E(B-type RAF,BRAFK601E)突变、PPARG 融合和 THADA 融合,一般无 BRAFV600E突变。微小 RNA(microRNAs)在 NIFTP 中同样存在异常表达。 结论 与 NIFTP 相关的分子可能成为其临床诊断的新分子标志物。

Objective The aim of this study was to review the molecular landscape of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Methods The relevant literatures about molecular profiling of NIFTP were retrospectively analyzed and summarized. Results The most common mutation in NIFTP was rat sarcoma viral oncogene homolog (RAS) mutation. B-type RAF (BRAFK601E) mutation, PPARG fusion, and THADA fusion also could be seen. There was usually no BRAFV600E mutation. miRNAs also were found to be differentially expressed in NIFTP. Conclusions The molecular profiling of NIFTP may become a new molecular marker for the diagnosis of NIFTP.

关键词: 伴乳头状癌核特征的非浸润性滤泡性甲状腺肿瘤; 分子研究; 综述

Key words: noninvasive follicular thyroid neoplasm with papillary-like nuclear features; molecular research; review

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