中国普外基础与临床杂志

中国普外基础与临床杂志

数据库研究第一部分:区域性医疗中心的结直肠癌与人群特征

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目的 分析目前版本的华西肠癌数据库(Database from Colorectal Cancer,DACCA)中,华西医院作为区域性医疗中心所服务的结直肠癌患者的人群特征。 方法 本次数据分析选取的 DACCA 版本为 2018 年 12 月 12 日更新版,其中数据项目包括:个体数据(性别、年龄、血型、身高、体质量及体质量指数)、地理数据(省份、市级及成都下设区市县)、职业与教育数据及主诊断数据,分别对各选取的数据项目作特征分析。 结果 按照条件筛选 DACCA 数据库获得 9 633 条可分析数据行。以 2005–2006 年为数据库建设的前后时间节点,2005 年以前(包括 2005 年)对数据库含量的贡献数值为 1 358 条,2005 年以后(不包括 2005 年)为 8 275 条。2005 年后的贡献率高于 2005 年以前 [1 358/11 比 8 275/13,95% CI 为(–625.337,–400.831),P<0.001]。9 633 条数据中,男性 4 669 条,女性 3 340 条,未核定数据 1 624 条;年龄为 13~104 岁、(59±13)岁,线性预测结果显示随年龄变化的线性稳定( $\hat y$ =0.016 1x+26.54,R2=3.42×105P=0.601 108);身高为 138~192 cm、(161±7)cm,线性预测结果显示随身高变化的线性稳定( $\hat y$ =0.110 5 x–60.911,R2=0.002 6,P=0.000 272);体质量为 27.5~80.5 kg、(59.38±10.27)kg,线性预测结果显示随体质量变化的线性升高( $\hat y$ =0.296 5x–537.24,R2=0.010 625,P=2.37×1014)。DACCA 数据库提供的地理源显示,华西医院服务地区与我国西部地区的定义存在差异。结直肠癌主要发生在直肠(68.64%),其中结肠癌主要发生在乙状结肠(27.06%),直肠癌主要发生在直肠肛管(13.34%)。 结论 DACCA 数据库显示的人群特征,可以初步反映结直肠癌病患在体质量和 BMI 上的升高变化,同时反映了以地理源为基础的区域分布特征,为进一步细化研究提供了线索。

Objective Screening the Database from Colorectal Cancer (DACCA) based on West China Hospial data by " Operation Date”, we purposed to analyze the population characteristics of colorectal cancer patients in regional medical center within recent Database Version. Methods The DACCA Version was updated in December 12th, 2018. Personal data (including sex, age, blood type, height, weight, and BMI), location data (including provinces, cities, and subordinate areas in Chengdu), occupation and education data, and main diagnosis data were included in the items. Characteristic analysis was performed on each selected data item. Results According to screening, 9 633 analytical data rows were obtained. Based on the database information, there were 24 consecutive years from 1995 to 2018 into every year. We set 2005 to 2006 as the time node for the database construction. The contribution to database before 2005 (including) was 1 358, while after 2005 (not including) were 8 275. The contribution rate (contribution numbers/years) after 2005 was higher than before 2005 [1 358/11 vs. 8 275/13, 95% CI was (–625.337, –400.831), P<0.001]. According to gender distribution, total male data were 4 669, female were 3 340, non-checked were 1 624. According to age distribution, age were from 13 to 104 [(59±13) years]. Linear prediction was used to predict the age distribution with the " year” as the time axis. The results showed the stable linear prediction ( $\hat y$ =0.016 1x+26.54, R2=3.42×105, P=0.601 108). According to height, height were from 138 cm to 192 cm [(161±7)cm], linear prediction results showed that the linear variation with height changes by value ( $\hat y$ =0.110 5 x–60.911, R2=0.002 6, P=0.000 272). According to weight, weight were from 27.5 kg to 80.5 kg [(59.38±10.27) kg], linear prediction results showed that the linear variation with height changes by value ( $\hat y$ =0.296 5x–537.24, R2=0.010 625, P=2.37×1014). Available 6 884 data showed the difference between serving areas by West China Hospital and official definition of western region. A total of 9 209 data obtained by analyzing main diagnosis, showed that the main site of disease was rectum (68.64%). Sigmoid was the main location of colon cancer (68.64%), and anal-rectal cancer was main of rectal cancer (27.06%). Conclusion Population characteristics from DACCA database could initially reflect the trend of increasing weight and BMI of colorectal cancer patients, and also reflect the regional distribution characteristics based on geographic information. They would be the clues for further database research.

关键词: 结直肠癌; 数据库; 大数据; 人群

Key words: colorectal cancer; database; bigdata; population

引用本文: 汪晓东, 李希, 何欣林, 李立. 数据库研究第一部分:区域性医疗中心的结直肠癌与人群特征. 中国普外基础与临床杂志, 2019, 26(2): 212-220. doi: 10.7507/1007-9424.201901052 复制

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