中国普外基础与临床杂志

中国普外基础与临床杂志

逆转mdr1基因导致肿瘤多药耐药性的研究进展

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目的 介绍目前mdr1基因导致肿瘤对化疗药物产生多药耐药性的研究进展。
方法 采用文献回顾的方式对肿瘤研究中采用的各种方法逆转mdr1基因导致肿瘤多药耐药性的文献进行综述。
结果 mdr1基因及其表达产物P糖蛋白的过度表达是导致肿瘤具有多药耐药性的重要原因,可以从mdr1基因的mRNA和P糖蛋白两个方面进行有效的逆转肿瘤多药耐药性。
结论 单一阻抑mdr1基因或P糖蛋白的表达,以逆转肿瘤多药耐药性的临床试验结果并不满意,多种方法联合应用是今后逆转肿瘤对化疗药物多药耐药性的研究热点。

【Abstract】Objective To review the advances in overcoming multidrug resistance of tumors caused by mdr1 gene.
Methods Different ways of overcoming multidrug resistance of tumors caused by mdr1 gene in the literatures were reviewed.
Results One of the important reasons causing multidrug resistance was due to the overexpression of mdr1 gene and its product Pglycoprotein. There were two ways to overcome multidrug resistance of tumors through mdr1 genes mRNA and its product Pglycoprotein effectively.
Conclusion The clinical test of the unitary way to overcome multidrug resistance of tumors is unsatisfactory, combining different ways to overcome multidrug resistance of tumors will be the hot spot of tumors research in the future.

关键词: 多药耐药基因; 多药耐药性

Key words: Multidrug resistance gene Multidrug resistance

引用本文: 李波,严律南. 逆转mdr1基因导致肿瘤多药耐药性的研究进展. 中国普外基础与临床杂志, 2004, 11(6): 554-557. doi: 复制

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