中国普外基础与临床杂志

中国普外基础与临床杂志

FGFR2 基因 rs2981582 位点多态性与中国人群乳腺癌易感性关系的 meta 分析

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目的 评价 FGFR2 基因 rs2981582 位点多态性与中国人群乳腺癌易感性的相关性。 方法 计算机检索 PubMed、Embase、Cochrane Library、中文科技期刊全文数据库、中国生物医学文献数据库、中国期刊全文数据库及万方数据库,检索有关 FGFR2 基因 rs2981582 位点的多态性与中国人群乳腺癌易感性关系的病例对照研究,检索时间为建库到 2018 年 3 月。采用 Stata 12.0 软件进行 meta 分析。 结果 共纳入 11 篇病例对照研究进行 meta 分析,其中病例组包括 5 921 例乳腺癌患者,对照组包括 5 919 位健康对照。meta 分析结果显示,对于中国人群而言,等位基因模型 [C 比 T:OR=1.07,95% CI 为(1.01,1.14),P=0.027]、杂合子模型 [CC 比 CT:OR=1.12,95% CI 为(1.01,1.24),P=0.026]、纯合子模型 [CC 比 TT:OR=1.19,95% CI 为(1.05,1.34),P=0.005]、显性模型 [CC 比 CT+TT:OR=1.10,95% CI 为(1.00,1.21),P=0.040] 及隐性模型 [TT 比 CC+CT:OR=1.19,95% CI 为(1.10,1.30),P<0.001]均与乳腺癌有关。 结论 FGFR2 基因 rs2981582 位点的多态性与中国人群乳腺癌的发生相关。

Objective To evaluate the association between fibroblast growth factor receptor 2 (FGFR2) rs2981582 polymorphism and the risk of breast cancer in Chinese population. Methods PubMed, Embase, Cochrane Library, Chinese Science and Technology Academic Journal, Chinese Biomedical Literature Database, Chinese Journal Full-text Database, and Wanfang database were searched to identify relevant articles that investigated the association of FGFR2 rs2981582 polymorphism with breast cancer risk from their inception to March 2018. A meta-analysis was performed by using the Stata 12.0 software. Results A total of 11 case-control studies were included in the present meta-analysis, including 5 921 breast cancer cases and 5 919 healthy controls. The pooled results indicated that, there was significant association between FGFR2 rs2981582 polymorphism and breast cancer susceptibility in Chinese population under allele model [C vs. T: OR=1.07, 95% CI was (1.01, 1.14), P=0.027], heterozygote model [CC vs. CT: OR=1.12, 95% CI was (1.01, 1.24), P=0.026]; homozygous model [CC vs. TT: OR=1.19, 95% CI was (1.05, 1.34), P=0.005]; dominant model [CC vs. CT+TT: OR=1.10, 95% CI was (1.00, 1.21), P=0.040], and recessive model [TT vs. CC+CT: OR=1.19, 95% CI was (1.10, 1.30), P<0.001]. Conclusion FGFR2 rs2981582 polymorphism was associated with risk of breast cancer in Chinese population.

关键词: 乳腺癌; 成纤维细胞生长因子受体 2; rs2981582 位点多态性; meta 分析

Key words: breast cancer; fibroblast growth factor receptor 2; rs2981582 polymorphism; meta-analysis

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