中国普外基础与临床杂志

中国普外基础与临床杂志

谷氨酰胺在肝切除术后营养支持应用的研究进展

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目的总结目前谷氨酰胺在肝切除术后营养支持的诊治情况及研究进展。方法通过检索国内外文献,就近年来谷氨酰胺在肝切除术后营养支持的相关文献加以综述。结果谷氨酰胺的给药上调了营养不良大鼠部分肝切除术后肝再生基因的表达,进而通过旁分泌和内分泌刺激细胞有丝分裂,影响肝细胞和肠细胞摄取氨基酸,促进肝细胞增殖。在临床应用中,谷氨酰胺可以提升患者术后肝功能和免疫功能,降低感染性并发症发生率,相对缩短住院时间,改善患者的临床结局。结论谷氨酰胺有益于肝功能的恢复,具有临床应用价值。

ObjectiveTo summarize the current status of research in nutritional support for glutamine after hepatectomy.MethodsThe literatures on nutritional support of glutamine after hepatectomy in recent years were reviewed by searching domestic and foreign literatures.ResultsThe administration of glutamine up-regulated the expression of liver regeneration genes after partial hepatectomy in malnourished rats, and then stimulated cell mitosis by paracrine and endocrine cells, affecting the uptake of amino acids by hepatocytes and intestinal cells, and promoting hepatocyte proliferation. In clinical applications, glutamine could improve postoperative liver function and immune function, reduce the incidence of infectious complications, relatively shorten the length of hospital stay, and improve the clinical outcome of patients.ConclusionsGlutamine is beneficial to the recovery of liver function and has clinical application value.

关键词: 谷氨酰胺; 肝切除; 营养支持; 综述

Key words: glutamine; hepatectomy; nutritional support; review

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